Anterior pituitary gland of human body growth and metabolism regulated by the hormone is secreted. 191 amino acid polypeptide hormone that China is a "growth hormone" as it is known. By binding to specific receptors in the body works. These receptors trigger multiple cellular responses when hormones are responsible for their dam. The results of growth hormone deficiency in growth related disorders. Sometimes sufficient levels of hormones in the body of a person with mental development, lack of receptors for growth hormone may also shown. Incorrect functioning of receptors Laron syndrome, dwarfism characterized by the delayed bone development, and administered growth hormone can result in apathy.
Growth hormone receptor and prolactin receptor with the number of cytokine receptors are proteins, and transmembrane protein belongs. There are two types of receptor structure -
620 amino acid membrane, bound, with a full-length transmembrane protein structure covering the region.
A soluble form, growth hormone binding protein extracellular domain of the full length receptor, known as match.
To enable system
Growth hormone receptor is a constitutive dimer. This activation occurs when growth hormone is tied. Of binding, tyrosine protein JAK2 kinase catalytic domains of the cell membrane at the bottom of, is by itself. The activation of JAK2 transphosphorylation of tyrosines of receptor phosphorylation is due to the following reasons. The target proteins and phosphorylation of target proteins directly binding allows muscle gaining secrets review.
There are two types of growth hormone receptor deficiency -
Type I - This type of growth hormone receptor gene is characterized by impairment in the growth hormone receptor to prevent binding. Increasing hormone levels in plasma as a result, the body is not use it.
Type II - growth hormone on cell surface properly tied However, issues related to process it.
The deficit disorder is rarely observed in an autosomal recessive inherited from the parents.
Many signs have pointed to the decline. Some of these are -
Severe mental development after birth
Short, hands and feet.
Increasing growth hormone levels in the body
Underdeveloped muscles and jaw
Abnormal development of the skull
High cholesterol levels in the blood
Fasting blood glucose level of less
Treatment1 or insulin-like growth factor - 1 - recombinant human growth hormone receptor by administration of IGF deficiency is treated. In addition, the lack of a child to avoid hypoglycemia is to eat frequently during childhood. 1 - a check on doctors' growth and development, blood glucose levels, and IGF keep the development of adverse effects. Exogenously administered IGF - naturally I hormones in the body increase the amount of circulating growth hormone, as well as the result 1. Gigantism and acromegaly caused by excessive activation of receptors may result. To activate autocrine activation of the receptors, the cancer cell can result in change Health info .
This condition can cause complications in -
Osteopenia or low bone mass
Low blood levels of glucose tour
A person or a child shows signs of disorder may actually be.If test results are positive, the doctor started treatment immediately receptor deficient development of the individual, growth, and metabolic activity is not interrupted.