Anterior pituitary gland of human body growth and metabolism
regulated by the hormone is secreted. 191 amino acid polypeptide hormone that China is a
"growth hormone" as it is known. By binding to specific receptors in
the body works. These receptors trigger multiple cellular responses when
hormones are responsible for their dam. The results of growth hormone
deficiency in growth related disorders. Sometimes sufficient levels of hormones
in the body of a person with mental development, lack of receptors for growth
hormone may also shown. Incorrect functioning of receptors Laron syndrome,
dwarfism characterized by the delayed bone development, and administered growth
hormone can result in apathy.
Growth hormone receptor and prolactin receptor with the
number of cytokine receptors are proteins, and transmembrane protein belongs.
There are two types of receptor structure -
620 amino acid
membrane, bound, with a full-length transmembrane protein structure covering the
region.
A soluble form,
growth hormone binding protein extracellular domain of the full length
receptor, known as match.
To enable system
Growth hormone receptor is a constitutive dimer. This
activation occurs when growth hormone is tied. Of binding, tyrosine protein
JAK2 kinase catalytic domains of the cell membrane at the bottom of, is by
itself. The activation of JAK2 transphosphorylation of tyrosines of receptor
phosphorylation is due to the following reasons. The target proteins and
phosphorylation of target proteins directly binding allows muscle gaining
secrets review.
Types
There are two types of growth hormone receptor deficiency -
Type I - This type
of growth hormone receptor gene is characterized by impairment in the growth
hormone receptor to prevent binding. Increasing hormone levels in plasma as a
result, the body is not use it.
Type II - growth
hormone on cell surface properly tied However, issues related to process it.
Because
The deficit disorder is rarely observed in an autosomal
recessive inherited from the parents.
Symptoms
Many signs have pointed to the decline. Some of these are -
Severe mental
development after birth
Short, hands and
feet.
Short stature
Increasing growth
hormone levels in the body
Underdeveloped
muscles and jaw
Abnormal
development of the skull
Thin skin
Delayed puberty
High cholesterol
levels in the blood
Fasting blood
glucose level of less
Obesity
Treatment
1 or insulin-like growth factor - 1 - recombinant human growth hormone
receptor by administration of IGF deficiency is treated. In addition, the lack
of a child to avoid hypoglycemia is to eat frequently during childhood. 1 - a
check on doctors' growth and development, blood glucose levels, and IGF keep
the development of adverse effects. Exogenously administered IGF - naturally I
hormones in the body increase the amount of circulating growth hormone, as well
as the result 1. Gigantism and acromegaly caused by excessive activation of
receptors may result. To activate autocrine activation of the receptors, the
cancer cell can result in change Health
info .
Complications
This condition can cause complications in -
Bone fractures
Osteopenia or low
bone mass
Low blood levels
of glucose tour
A person or a child shows signs of disorder may actually
be.If test results are positive, the doctor started treatment immediately
receptor deficient development of the individual, growth, and metabolic
activity is not interrupted.
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